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Home > Journal of Shalamar Medical and Dental College > Volume 2 Issue 1 of Journal of Shalamar Medical and Dental College

Impact of Exposure of Chemical Fumes on Blood Pressure and Peak Expiratory Flow Rate in Industrial Workers of Faisalabad |
Journal of Shalamar Medical and Dental College
Journal of Shalamar Medical and Dental College

Article Info
Authors

Volume

2

Issue

1

Year

2021

ARI Id

1682060070609_2966

Pages

22-28

DOI

10.53685/jshmdc.v2i1.9

PDF URL

https://journal.smdc.edu.pk/index.php/journal/article/download/9/4

Chapter URL

https://journal.smdc.edu.pk/index.php/journal/article/view/9

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INTRODUCTION

Air pollution and global warming are continuously on the rise due to modernization, industrialization and increased number of vehicles on the road across the world1. Exposure to noxious gases, chemicals and air born particulate matter (PM) emitted from the industries are adversely affecting the human health leading to serious health crisis.

 

Shape3

PM is a complex mixture of toxic substances including element carbon, polycyclic hydro- carbons, organic carbon, other solid and liquid compounds that remain suspended in the atmo- sphere. PM has been proved to be harmful and injurious to health2.

Literatures shows that exposure to a high concen- tration of air pollutants is associated with impaired pulmonary functions1-3. Fine and ultrafine part- iculate matter in air pollution possesses oxidative capacity which is easily deposited in air ways and results in oxidative damage and inflammation leading to obstruction of airways. Air way obstruction leads to decline in lung function test including peak expiratory flow rate (PEFR). Peak expiratory flow rate is a direct simple and reliable parameter for assessment of lung functions and helpful in measuring the obstruction of even smaller air ways3.

Several previous epidemiological studies have reported the occurrence of cardio vascular diseases with exposure to chemicals like Sulphur dioxide, carbon dioxide, nitric dioxide and PM emitted from the factories3,4. Air pollution causes the oxidative stress and damage to vascular endothelium and severe vasoconstriction3. Strong evidences are also available showing that elevation in physiological levels of neuro-transmitters like adrenaline, dopamine and serotonin are possible causes of sever vaso-constriction and potentially increase the systemic blood pressure due to exposure to industrial chemicals4. Various previous studies also documented that people working or living in the vicinity of chemical industries having more exposure to chemical fumes are at a greater risk of cardiopulmonary diseases5.Link between long- term exposure to air pollution and cardiovascular diseases is well established, however literature concerning effects on blood pressure is limited3.Numerous previous studies have already assessed the cardiopulmonary functions in subjects having exposure to chemicals and established its

link with cardiac diseases but its impact on blood pressure still remains a question to be answered5. Furthermore, there is paucity of data showing the association of lung function parameters like PEFR and blood pressure in people who are exposed to industrial pollutants. This study was designed to assess the changes in PEFR and blood pressure in subjects having exposure to chemicals emitted from the industries in Faisalabad that is a hub of the industries. We also aimed to determine the association between the changes in blood pressure and PEFR in these male subjects.

The objectives of the were to determine the impact of duration of exposure to industrial chemical fumes on Peak Expiratory Flow Rate (PEFR) and blood pressure of the industrial workers and to find out the association between changes in blood pressure and PEFR due to exposure to industrial chemical fumes in these subjects.

MATERIALS AND METHODS

This cross-sectional study was performed at Aziz Fatimah Medical and Dental College, Faisalabad. Prior to study, ethical approval was taken from institutional ethical committee and informed consent was taken from the part-icipants. Free camp in the industrial area was arranged for three days in September 2020. Non-smokers male subjects aged 20 to 60 years working in chemical industries were included in the study. Thorough history was recorded in a predesigned proforma. Healthy non-smoker male subjects with exposure to chemicals for at least one year or more were included in the study. Hundred and fifty-one subjects who met inclusion criteria were enrolled in the study by convenient sampling technique. Subjects with known pulmonary diseases like asthma, tuberculosis, chronic obstructive pulmonary disease, cardiovascular diseases, smokers and female workers were excluded from the study.

Weight in kilogram and height in centimeters were recorded using weight and BMI was calculated by dividing weight in kilogram by square of height in meters (kg/m2). PEFR values were recorded using Wrights handheld peak flow meter. For PEFR the participants were asked to blow out after deep inspiration, into the nozzle of peak expiratory flow meter, sealed tightly by lips. Three readings in Liters/Minute were taken from each participant and average was recorded for data analysis. Systolic and diastolic blood pressures in sitting posture were determined by auscultatory method using mercury sphygmomanometer after relaxing the subjects for at least 5 minutes. Sys-tolic readings were recorded on appearance of clear Korotkoff sounds and diastolic readings were recorded with disappearance of these sounds.

Data was statistically analyzed by SPSS version 22. Age, height, weight, BMI, blood pressure and PEFR were expressed as mean ± SD. Means of all parameters were compared by ANOVA. Multiple comparison done by Post hoc test (Tukey HSD). Association of PEFR with systolic and diastolic blood pressure was determined by regression analysis. A p value ≤0.05 was taken as significant.

RESULTS

This study comprised of 151 male participants having exposure to chemicals. Demographics of the study population are presented in the table 1. Table 2 is indicating that the systolic and diastolic blood pressures were significantly raised in sub- jects with prolonged exposure to industrial chemical fumes. Significant differences were observed in mean systolic (p value = 0.011) and diastolic (p value = 0.037) blood pressure with respect to duration of exposure. On the other hand, PEFR value decline with increase in duration of exposure to industrial chemical fumes.

Shape5 Post-hoc groups comparison (3 groups on the basis of duration of chemical exposure) of blood pressure and PEFR with respect to duration of chemical

exposure shows statistically significant difference in mean systolic BP between the groups having exposure of 5 to 10 and greater than 10 years (p value = 0.014). However, concerning mean diastolic BP and PEFR, statistically significant differences were found in groups having exposure less than 5 and greater than 10 years with p values

0.029 and 0.001 respectively (Table 3).

Regression analysis shows significant negative association between diastolic blood pressure and PEFR (p value = 0.003). Current results also show weak negative association between PEFR and systolic BP, however it was not statistically significant (p = value 0.92) (Table 4).

On analyzing the association between these parameters with duration of exposure, we found significant positive association of duration of exposure with systolic (β =0.52, p value = 0.000) diastolic blood pressure (β =0.165, p value = 0.047). Beta coefficient of 0.52 and 0.165 indic- ates that increase in duration of exposure by one year will increase systolic and diastolic BP by 0.52-

Table 1: Descriptive of Study Population (n=151)

Variables

Mean± SD

Age (year)

38.76±12.13

Height (cm)

170.07±12.05

Weight (kg)

78.12±12.79

Body mass Index (kg/m2)

38.19±4.72

Peak expiratory rate( PEFR) (L/min)

343.33±86.4

Systolic Blood pressure (mmHg)

127.45±13.07

Diastolic Blood pressure (mm Hg)

81.49± 8.36

 

 

0.165 mmHg.

 

Table 2: Comparison of Blood Pressure and PEFR with Respect to Duration of Chemical Exposure

Dependent variable

Duration of exposure in years

N (151)

Mean

SD

p value*

Systolic BP

Less than 5

62

124.92

11.682

0.011*

(mm Hg)

5-10

34

125.29

12.119

 

 

Greater than 10

55

131.64

14.242

 

Diastolic BP

Less than 5

62

131.64

14.242

0.037*

(mm Hg)

5-10

34

131.64

14.242

 

 

Greater than 10

55

131.64

14.242

 

PEFR

Less than 5

62

366.90

89.185

0.001*

(L/min)

5-10

34

352.44

73.521

 

 

Greater than 10

55

311.13

82.008

 

One-way ANOVA test was applied

*p-value 0.05 taken as significant, PEFR= peak expiratory flow rate BP=Blood Pressure

Table 3: Post-hoc comparison of Blood Pressure and PEFR with Respect to Duration of Chemical Exposure

Dependent Variable

Duration Exposure Categories

Duration Exposure Categories

Mean Difference

Std. Error

p value

Systolic BP

Less than 5

5-10

-.375

2.725

0.990

(mm Hg)

 

Greater than 10

-6.717

2.365

0.014*

 

5-10

Less than 5

.375

2.725

0.990

 

 

Greater than 10

-6.342

2.785

0.062

 

Greater than 10

Less than 5

6.717

2.365

0.014*

 

 

5-10

6.342

2.785

0.062

Diastolic BP

Less than 5

5-10

2.386

1.757

0.366

(mm Hg)

 

Greater than 10

-2.245

1.525

0.307

 

5-10

Less than 5

-2.386

1.757

0.366

 

 

Greater than 10

-4.631

1.796

0.029*

 

Greater than 10

Less than 5

2.245

1.525

0.307

 

 

5-10

4.631

1.796

0.029*

PEFR

Less than 5

5-10

14.462

17.775

0.695

(L/min)

 

Greater than 10

55.776

15.428

0.001*

 

5-10

Less than 5

-14.462

17.775

0.695

 

 

Greater than 10

41.314

18.171

0.063

 

Greater than 10

Less than 5

-55.776

15.428

0.001*

 

 

5-10

-41.314

18.171

0.063

Tukey test was applied

*p-value <0.05 was considered as statistically significant.

 

However, PEFR is negatively associated with duration of exposure with PEFR (β=-2.733, p value 0.001). Beta coefficient of -2.733 shows that an

increase in duration of exposure by one year, will decrease PEFR by 2.733 L/min.

 

Table 4: Regression Analysis between Blood Pressure and Peak Expiratory Flow Rate

Dependent Variables

Beta coefficient (β)

Standard error (SE)

p value

Diastolic blood pressure (mm Hg)

-2.469

0.822

0.003*

Systolic blood pressure (mm Hg)

-0.910

0.537

0.92

p-value 0.05 taken as significant PEFR= peak expiratory flow rate

*PEFR is the independent variable

 

DISCUSSION

Environmental pollution due to increasing number of industries worldwide is a great public health concern. Fumes of noxious gases, PM and nume- rous other chemicals in atmosphere causes injurious effects on human body that affects the quality of life of these individuals1.This study was performed to highlight hazardous effects of industrial chemical fumes and PM on the heart and lungs, as lungs are in direct contact with the atmospheric air and are naturally first to bear the brunt of the atmospheric contamination. Inhalation of noxious gases with fine PM get deposited in the alveolar walls and bronchioles causing decrease in the elastic recoil of the lungs leading irreversible air flow limitation and compromised lung functions5. The current study determined the blood pressure and peak expiratory rate of the subjects having history of long-term exposure to chemical fumes emitted from the industries.

Baseline measurements of PEFR in the study population were 343.33 L/min for men that were reduced with increase in duration of the exposure to chemical fumes emitted from the industries. These base line values are in accordance with

 

Table 5: Regression Analysis Between Blood Pressure(s), PEFR and Exposure Duration

Dependent Variables

Beta coefficient (β)

Standar d error (SE)

p value

Diastolic blood pressure

(mm Hg)

0.165

0.082

0.047

 

Systolic blood pressure (mm Hg)

 

0.520

 

0.123

 

0.00*

 

PEFR

(L/min)

 

-2.733

 

0.833

 

0.00*

*Exposure duration is the independent variable PEFR= Peak Expiratory Flow Rate

p-value 0.05 taken as significant

 

another previous study conducted at Faisalabad by Komal et al that reported similar values for residents of Faisalabad6.

We noticed significant lower PEFR values in workers having exposure of chemicals for greater than 10 years as compared to worker having duration exposure less than 5 years. Regression analysis show significant negative impact of duration of exposure on PEFR. Beta coefficient of

-2.733 shows that increase in duration of exposure by one year, will decreases PEFR by 2.733 L/min. Our findings are in accordance with study conducted in Hyderabad, India, that also observed decrease in PEFR values with increase in duration of exposure to chemical fumes5.

Current study found increase in diastolic blood pressure with increasing the duration of exposure to chemicals. On multiple comparison by post hoc test we found significant difference in mean diastolic blood pressure of subjects having exposure of less than five years and greater than 10 years. Comparatively higher blood pressure was

 

 

noticed in subjects having exposure more than 10 years than with exposure less than 5 years. Our findings are further affirming by results of regression analysis showing positive relation of diastolic blood pressure with duration of exposure. Beta coefficient of 0.165 indicates that increase in duration of exposure by one year will increase diastolic BP by 0.165 mmHg. Our findings are inconsistent with the previous studies by Lina et al and Jacobs et al3,7. They documented negative correlation between diastolic blood pressure and increase in duration of exposure to PM in air pollution3,7.

Current study found that systolic blood pressure is significantly increasing with increase in the duration of chemical exposure. Our results indicate that subjects having exposure of 10 years have significantly higher systolic blood pressure as compared to subjects having exposure between5 to 10 years. These findings are further strengthened by the results of regression analysis showing positive impact of duration of exposure on systolic blood pressure.

Beta coefficient of 0.52 indicates that increase in duration of exposure by one year will increase systolic BP by 0.52 mmHg. Results of current study are justified by the results of previous study that reported the delayed increase in systolic blood pressure due to short term exposure to air pollution having PM8.Suggestive pathway for PM induced delayed increase in the systolic pressure is an adrenal stress response i.e. increased glucocorticoids due to activation of hypo- thalamic–pituitary–adrenal axis8. Our results are also in accordance with study conducted by Jacob et al, that demonstrated significant elevation in systolic blood pressure on exposure to air pollution7.Arterial stiffness and reduced elasticity due to exposure to ambient air pollution is another possible cause of elevation of systolic blood pressure9.Scheer et al did not find any association between systolic pressure and air pollution,

however they found positive association between pulse pressure and air pollution and also observed arterial stiffness in vascular walls10. On the other hand, Lina et al documented decrease in systolic blood pressure with presence of high PM and other toxic substances in air3.

There was a significant negative association between diastolic blood pressure and PEFR. However, no association was found between systolic blood pressure and PEFR values. No literature was found concerning association bet- ween these parameters that are being affected by air pollution and are the primary indicators for cardiopulmonary dysfunction. To the best of our knowledge this is the first study in Pakistan highlighting association between diastolic blood pressure and PEFR showing the strength of this study. This research will open new horizon for future researches on a broader scale to validate this association.

Limitations

We cannot infer causal association between the parameters due cross-sectional study design.

CONCLUSION

There was a decrease in PEFR value with increasing duration of exposure to industrial chemical fumes. Systolic and diastolic blood pressures were significantly raised in subjects with increase duration of chemical exposure. PEFR has significant negative association with Diastolic blood pressure. No correlation was found between PEFR and systolic blood pressure.

Conflicts of interest

The authors have no conflicts of interest to report.

Contributors

Dr. Shireen Jawed contributed to study design, data collection, manuscripts writing, revise and approve the article. Dr. Benash Altaf contributed to study design, manuscripts writing, revise and approve the

article. Qaisar Suhail did the statistical analysis and result interpretation. Dr. Noor-i-Kiran Naeem and Dr. Farah Amir Ali contributed to study design, data collection, revise and approve the article. All authors are equally accountable for research work and data.

REFERENCES

  • Tóthová D. Respiratory Diseases in Children and Air Pollution – The Cost of – Illness Assessment in Ostrava City. Cent Eur J Public Policy.2020; 14(1): 43-56. https://doi.org/10.2478/cejpp-2020-0003

  • Kurt OK, Zhang J, Pinkerton KE. Pulmonary health effects of air pollution. Curr Opin Pulm Med. 2016; 22(2): 138-43. doi:10.1097/MCP.0000000000000248.

  • Mu L, Deng F, Tian L, Li Y, Swanson M, Ying J, et al. Peak Expiratory Flow, Breath Rate and Blood Pressure in Adults with Changes in Particulate Matter Air Pollution during the Beijing Olympics: A Panel Study. Environ Res. 2014; 133: 4–11.

  • Kim KW, Won YL, Ko KS, Heo KH, Chung YH. The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers. Toxicol Res. 2012; 28(4): 269-77. doi: 10.5487/TR.2012.28.4.269.

  • Padaki SK, Amrut D, Kokiwar P. Peak expiratory flow rate in asymptomatic male workers exposed to chemical fumes, in various industries of Hyderabad. Int J Med Res Health Sci. 2014; 3(4): 870-5.

  • Atta K, Zia S, Jabeen F. Impact of Anthropometric Parameters on Peak Expiratory Flow Rate. J Aziz Fatm Med Den College. 2019; 1(2): 63-6.

  • Jacobs L, Buczynska A, Walgraeve C, Delcloo A, Potgieter Vermaak S, Van Grieken R, et al. Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons. Environ Res. 2012; 117: 60-7. doi: 10.1016/j.envres.2012.05.003.

  • Fedak KM, Good N, Walker ES, Balmes J, Brook RD, Clark ML, et al. Acute Effects on Blood Pressure Following Controlled Exposure to Cookstove Air Pollution in the STOVES Study. J Am Heart Assoc. 2019; 8(14): e012246. doi: 10.1161/JAHA.119.012246.

  • Cai Y, Zhang B, Ke W, Feng B, Lin H, Xiao J, et al. Associations of Short-Term and Long-Term Exposure to Ambient Air Pollutants with Hypertension: A Systematic Review and Meta-Analysis. Hypertension.

    2016; 68(1): 62-70. doi:

    10.1161/HYPERTENSIONAHA.116.07218.

  • Scheers H, Nawrot TS, Nemery B, Casas L. Changing places to study short-term effects of air pollution on cardiovascular health: a panel study. Environ Health. 2018; 17(1): 80. doi: 10.1186/s12940-018-0425-7.

     

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